New forms of insulin Therapy
Number of View :62 New insulins, new route of administration e.g. intra-peritoneal delivery device Nasal spray implantable pellets close loop artificial pancreas – controlled variable rate drug delivery with an in-vivo glucose sensor continuosly monitoring glucose level and directing operation of the devise. In-vivo glucose sensor not very practcable islet cell and pancreas transplantation i.e. [...]
Anti emetic drugs
Number of View :194Anti emetic drugs · For motion sickness · Promethazine -H1 antagonist (classical) – Used as a sedative in children (it is a very safe sedative) – Also has antimuscarinic actions · It is very effective at preventing motion sickness (since the vestibular afferents input in the vomiting center which has H1 and [...]
Drugs which causes nausea and vomiting
Number of View :194· Apomorphine (and Bromocriptide) – A D2 agonist used in the treatment of parkinsons; · It acts on the D2 receptor in the CTZ to cause vomiting · Morphine – In excess amounts, also acts on D2 receptors · Syrup of Ibericat - Irritates the gut, causing activation of 5HT3 receptors · [...]
Anti Emetics – Theories of nausea and vomiting
Number of View :196 ANTI EMETICS Theories of nausea and vomiting · The main area in the brain responsible for vomiting is the vomiting center · This area is located in the lateral reticular formation of the medulla · It receives input from many areas: · Chemoreceptor trigger zone · Located in the floor of [...]
Log Cell Kill Hypothesis used in Cytotoxic Drugs for Cancer Chemotherapy
Number of View :389THE LOG CELL KILL HYPOTHESIS Cytotoxic drugs act by first-order kinetics; that is, at a given dose, they kill a constant fraction of the tumor cells rather than a fixed number of cells. For example, a drug dose that would result in a three-log cell kill (i.e., 99.9% cytotoxicity) would reduce the [...]