The “Triple Response” (Triple Response of Lewis)
Number of View :44The “Triple Response” (Triple Response of Lewis) Intradermal injection of histamine causes a characteristic red spot, edema, and flare response that was first described many years ago. The effect involves three separate cell types: smooth muscle in the microcirculation, capillary or venular endothelium, and sensory nerve endings. At the site of injection, [...]
Clinical Uses of Histamine
Number of View :42Clinical Uses of Histamine - In pulmonary function laboratories, histamine aerosol has been used as a provocative test of bronchial hyperreactivity. Histamine has no other current clinical applications. Toxicity & Contraindications in use of Histamine - Adverse effects of histamine release, like those following administration of histamine, are dose-related. Flushing, hypotension, tachycardia, [...]
Tissue, Organ, System and Metabolic Effects of Histamine
Number of View :53Tissue, Organ, System and Metabolic Effects of Histamine - Histamine exerts powerful effects on smooth and cardiac muscle, on certain endothelial and nerve cells, on the secretory cells of the stomach, and on inflammatory cells. - Sensitivity to histamine varies greatly among species – Effects of Histamine on the Nervous [...]
Drug Resistance in Cancer Chemotherapy
Number of View :29 Drug Resistance in Cancer Chemotherapy A fundamental issue in cancer chemotherapy is the development of cellular drug resistance. Some tumor types, eg, malignant melanoma, renal cell cancer, and brain cancer, exhibit primary resistance, ie, absence of response on the first exposure, to currently available agents. The presence of inherent drug resistance is [...]
Mechanism of Diuretic Action of Carbonic Anhydrase Inhibitors
Number of View :255Mechanism and Site of Action of carbonic anhydrase inhibitor diuretics Proximal tubular epithelial cells are richly endowed with the zinc metalloenzyme carbonic anhydrase, which is found in the luminal and basolateral membranes (type IV carbonic anhydrase, an enzyme tethered to the membrane by a glycosylphosphatidylinositol linkage), as well as in the cytoplasm [...]